Advances in Chemistry and Biochemistry Sciences
Volume 3 | Issue 3 | Pages 01-09
Preliminary phytochemical and in-vitro pharmacological evaluation of whole plant extracts of Ziziphus nummularia Burn. f.
Manjusha Choudhary 1*, Ojashvi Sharma 1, Nitesh Choudhary 2, Vikaas Budhwaar 3, Vineet Mehta 1
1Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136118, Haryana, India.
2R. P. Inderprastha Institute of Technology, Karnal-132001, Haryana, India.
3Department of Pharmaceutical Sciences, Maharishi Dyanand University, Rohtak-124001, Haryana, India.
The aim of the present study is to evaluate the in-vitro pharmacological activities of various fractions of hydroalcoholic extracts of Ziziphus nummularia Burn. f. The anti-inflammatory activity was performed by heat induced haemolysis, membrane stabilization and protein denaturation inhibition assay. Diclofenac sodium was used as standard drug. The immunomodulatory activity was carried out on human neutrophils by assessing nitrobluetetrazolium test, neutrophil locomotion and chemotaxis. All the extracts were tested at concentrations viz. 100, 250, 500 and 1000 μg/ml. The various extracts showed significant activity on in vitro human neutrophils and protein denaturation which are comparable to standard and control at different concentration indicating the possible immune-stimulating, anti-inflammatory and antimicrobial effect.