Advances in Cosmetics and Dermatology
Volume 1 | Issue 1 | Pages 01-08
Pomegranate seed oil increases the expression of alpha 1 type I collagen, elastin and telomerase reverse transcriptase genes in Oryzias latipes embryos
Ana Ramírez-Boscá 1,2, Miguel Carrión-Gutiérrez 1*, Vicente Navarro-López 1,2
Background: Human skin is subjected to many environmental factors that cause its premature aging, such as sun light radiation and pollution. The skin aging involves a loss of firmness and elasticity, as well as the decrease in the rate of cell renewal. The cosmetic industry includes ingredients that proclaim to combat these damages on the skin. In this report, pomegranate seed oil has been tested as a natural ingredient to be included in cosmetics for its potential ability to counteract the process of skin aging. The study was performed on medaka fish embryos because of the advantages that this animal model offers and its extended use as a model of human biology. To evaluate the role of pomegranate seed oil, we analysed the effect on the expression of three genes that encode for key proteins involved in maintaining firmness, Col1, elasticity, Eln, and cell renewal, Tert.
Results: Our results showed that, after treatment of these embryos with 50% pomegranate seed oil the expression of Col1 was increased, but not that of Eln or Tert. On the other hand, treatment with 100% pomegranate seed oil did not affect Col1 expression but activated Eln and Tert expression.
Conclusions: These results suggest that the use of pomegranate seed oil as a cosmetic ingredient may counteract the effects of skin aging.